Pharmacogenetic workup of perioperative serotonin syndrome

Nicole C. Beatty, Wayne T. Nicholson, Loralie J. Langman, Timothy B. Curry, John H. Eisenach

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Serotonin syndrome is gaining attention in perioperative and chronic pain settings due to the growing prevalence of multimodal therapies that increase serotonin levels and thereby heighten patient risk. A patient's genetic make-up may further increase the risk of serotonin syndrome. A case of serotonin syndrome on emergence after general anesthesia is presented. A subsequent cytochrome P4502D6 genetic test result suggested a potential alteration in metabolism. For this patient, who was taking combination antidepressant medications and receiving common perioperative medicines, additive pharmacodynamic effects converged with a pharmacogenetic predisposition, resulting in serotonin syndrome.

Original languageEnglish (US)
Pages (from-to)662-665
Number of pages4
JournalJournal of Clinical Anesthesia
Issue number8
StatePublished - Dec 1 2013


  • Duloxetine
  • Multimodal therapy
  • P4502D6 chromosome
  • Perioperative serotonin syndrome
  • Pharmacogenetics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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