Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus

Yasuo Inoshima; Yasuhiro Ikeda; Mariko Kohmoto; Marcelo Ricardo Pecoraro; Masayuki Shimojima; Yukako Shimojima; Gouki Inada; Yasushi Kawaguchi; Keizo Tomonaga; Takayuki Miyazawa; Takeshi Mikami

doi:10.1292/jvms.58.925

Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus

Yasuo Inoshima
, Yasuhiro Ikeda
, Mariko Kohmoto
, Marcelo Ricardo Pecoraro
, Masayuki Shimojima
, Yukako Shimojima
, Gouki Inada
, Yasushi Kawaguchi
, Keizo Tomonaga
, Takayuki Miyazawa
, Takeshi Mikami

Molecular Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.

Original language	English (US)
Pages (from-to)	925-927
Number of pages	3
Journal	Journal of Veterinary Medical Science
Volume	58
Issue number	9
DOIs	https://doi.org/10.1292/jvms.58.925
State	Published - Sep 1996

Keywords

Antibody
FIV
Neutralization test

ASJC Scopus subject areas

General Veterinary

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10.1292/jvms.58.925

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Inoshima, Y., Ikeda, Y., Kohmoto, M., Pecoraro, M. R., Shimojima, M., Shimojima, Y., Inada, G., Kawaguchi, Y., Tomonaga, K., Miyazawa, T., & Mikami, T. (1996). Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus. Journal of Veterinary Medical Science, 58(9), 925-927. https://doi.org/10.1292/jvms.58.925

Inoshima, Y, Ikeda, Y, Kohmoto, M, Pecoraro, MR, Shimojima, M, Shimojima, Y, Inada, G, Kawaguchi, Y, Tomonaga, K, Miyazawa, T & Mikami, T 1996, 'Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus', Journal of Veterinary Medical Science, vol. 58, no. 9, pp. 925-927. https://doi.org/10.1292/jvms.58.925

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abstract = "The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.",

keywords = "Antibody, FIV, Neutralization test",

author = "Yasuo Inoshima and Yasuhiro Ikeda and Mariko Kohmoto and Pecoraro, \{Marcelo Ricardo\} and Masayuki Shimojima and Yukako Shimojima and Gouki Inada and Yasushi Kawaguchi and Keizo Tomonaga and Takayuki Miyazawa and Takeshi Mikami",

year = "1996",

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doi = "10.1292/jvms.58.925",

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AU - Inoshima, Yasuo

AU - Ikeda, Yasuhiro

AU - Kohmoto, Mariko

AU - Pecoraro, Marcelo Ricardo

AU - Shimojima, Masayuki

AU - Shimojima, Yukako

AU - Inada, Gouki

AU - Kawaguchi, Yasushi

AU - Tomonaga, Keizo

AU - Miyazawa, Takayuki

AU - Mikami, Takeshi

PY - 1996/9

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AB - The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.

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KW - Neutralization test

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Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus

Abstract

Keywords

ASJC Scopus subject areas

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