Persistence of asthma biologic use in a US claims database

Jacob T. Maddux, Jonathan W. Inselman, Molly M. Jeffery, Regina W. Lam, Nilay D. Shah, Matthew A. Rank

Research output: Contribution to journalArticlepeer-review


Background: Little is known on the persistence of asthma biologic use in clinical practice. Objective: To evaluate the persistence of asthma biologic use and time to clinical response in clinical practice. Methods: A cohort of people with asthma who used at least 1 asthma biologic was constructed using data from 2003 to 2019 in the OptumLabs Data Warehouse. Treatment persistence was defined by the length of time that a person continuously used an asthma biologic, allowing for a lapse in use up to 4 months before confirming that a person stopped. Clinical response to treatment (defined as a decline in asthma exacerbations of at least 50% compared with the 6 months before starting an asthma biologic) was described over time and in relation to biologic persistence. Results: There were 9575 people who had at least 1 episode of asthma biologic use. There were 5319 people (64%, 95% confidence interval, 63%-65%) who completed 6 months or more on an asthma biologic and 3284 (45%, 95% confidence interval, 44%-46%) who completed 12 months or more. Of people with 1 or more asthma exacerbation 6 months before index biologic use, 63%, 76%, 80%, and 81% realized a 50% or more reduction in postindex asthma exacerbations in the first 6 months, 6 to 12 months, 12 to 18 months, and 18 to 24 months, respectively. Conclusion: Between 48% and 64% of people remained on an asthma biologic for 6 months or more after first use. Most people who achieved a reduction in asthma exacerbations did so in the first 6 months of treatment.

Original languageEnglish (US)
Pages (from-to)648-654
Number of pages7
JournalAnnals of Allergy, Asthma and Immunology
Issue number6
StatePublished - Dec 2021

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


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