TY - JOUR
T1 - Perioperative events in living and deceased donor liver transplant recipients
T2 - A case control study
AU - Gali, Bhargavi
AU - Plevak, David J.
AU - Nagorney, David M.
AU - Rosen, Charles B.
AU - Heimbach, Julie K.
AU - Dierkhising, Ross A.
AU - Findlay, James Y.
PY - 2011
Y1 - 2011
N2 - Living donor liver transplantation (LD) has been implemented as an alternative to deceased donor transplantation (DD). We reviewed the perioperative course of recipients of LD and recipients of DD at our institution with specific aims to compare intraoperative events, early complication rates, resource utilization, and patient survival. Methods: Following Institutional Review Board (IRB) approval, the first forty LD cases were retrospectively matched by age, sex, and primary reason for transplant with controls that underwent DD between June 30, 2000 and January 25, 2005. Preoperative data, intraoperative variables, and immediate postoperative data were collected. Statistical analysis included signed rank test, McNemar's test, Wald statistics, and stratified Cox proportional hazards model. Results: Calculated Model for End Stage Liver Disease (MELD) scores were higher for DD (median 18 vs. 14 with p=0.04). Anesthesia time was longer in LD (median 7.1 vs. 6.5, p=0.02). Hospital length of stay (LOS) was higher in LD (median 12 vs. 8 days, P=0.002). Seven of the 40 (17%) LD were deceased at the time of data collection, as were four (10%) of the DD. Conclusions: Comparison of DD and LD at our institution revealed few significant differences in perioperative variables. LD may have more postoperative complications and longer hospital stays but similar patient survival.
AB - Living donor liver transplantation (LD) has been implemented as an alternative to deceased donor transplantation (DD). We reviewed the perioperative course of recipients of LD and recipients of DD at our institution with specific aims to compare intraoperative events, early complication rates, resource utilization, and patient survival. Methods: Following Institutional Review Board (IRB) approval, the first forty LD cases were retrospectively matched by age, sex, and primary reason for transplant with controls that underwent DD between June 30, 2000 and January 25, 2005. Preoperative data, intraoperative variables, and immediate postoperative data were collected. Statistical analysis included signed rank test, McNemar's test, Wald statistics, and stratified Cox proportional hazards model. Results: Calculated Model for End Stage Liver Disease (MELD) scores were higher for DD (median 18 vs. 14 with p=0.04). Anesthesia time was longer in LD (median 7.1 vs. 6.5, p=0.02). Hospital length of stay (LOS) was higher in LD (median 12 vs. 8 days, P=0.002). Seven of the 40 (17%) LD were deceased at the time of data collection, as were four (10%) of the DD. Conclusions: Comparison of DD and LD at our institution revealed few significant differences in perioperative variables. LD may have more postoperative complications and longer hospital stays but similar patient survival.
KW - Biliary complications
KW - Intraoperative complications
KW - Perioperative morbidity
KW - Transfusion requirements
KW - Wound infections
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U2 - 10.2174/1874418401105010008
DO - 10.2174/1874418401105010008
M3 - Review article
AN - SCOPUS:79955054353
SN - 1874-4184
VL - 5
SP - 8
EP - 14
JO - Open Transplantation Journal
JF - Open Transplantation Journal
ER -