Perils and pitfalls of small negative clinical trials

G. Richard Locke, Alan R. Zinsmeister

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


In summary, we have tried to illustrate the perils and pitfalls of small negative clinical trials. They do not show that two treatments are different but they do not prove they are the same either. They prove little. Our goal in the long run has to be to do fewer of them. Why should a patient enroll in a study which cannot give a meaningful result? The burden is on all of us to cooperate and perform larger more definitive studies.

Original languageEnglish (US)
Pages (from-to)2185-2186
Number of pages2
JournalAmerican Journal of Gastroenterology
Issue number10
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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