Percutaneous intervention in peripheral artery disease improves calf muscle phosphocreatine recovery kinetics: A pilot study

Amy M. West, Justin D. Anderson, Frederick H. Epstein, Craig H. Meyer, Klaus D. Hagspiel, Stuart S. Berr, Nancy L. Harthun, Arthur L. Weltman, Brian H. Annex, Christopher M. Kramer

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We hypothesized that percutaneous intervention in the affected lower extremity artery would improve calf muscle perfusion and cellular metabolism in patients with claudication and peripheral artery disease (PAD) as measured by magnetic resonance imaging (MRI) and spectroscopy (MRS). Ten patients with symptomatic PAD (mean ± SD: age 57 ± 9 years; ankle-brachial index (ABI) 0.62 ± 0.17; seven males) were studied 2 months before and 10 months after lower extremity percutaneous intervention. Calf muscle phosphocreatine recovery time constant (PCr) in the revascularized leg was measured by 31P MRS immediately after symptom-limited exercise on a 1.5-T scanner. Calf muscle perfusion was measured using first-pass gadolinium-enhanced MRI at peak exercise. A 6-minute walk and treadmill test were performed. The PCr recovery time constant improved significantly following intervention (91 ± 33 s to 52 ± 34 s, p < 0.003). Rest ABI also improved (0.62 ± 0.17 to 0.93 ± 0.25, p < 0.003). There was no difference in MRI-measured tissue perfusion or exercise parameters, although the study was underpowered for these endpoints. In conclusion, in this pilot study, successful large vessel percutaneous intervention in patients with symptomatic claudication, results in improved ABI and calf muscle phosphocreatine recovery kinetics.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalVascular Medicine
Issue number1
StatePublished - Feb 2012


  • calf muscle
  • cardiovascular magnetic resonance
  • lower extremity percutaneous revascularization
  • perfusion
  • peripheral artery disease
  • phosphocreatine recovery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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