Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration

Jennifer L. Whitwell; Clifford R. Jack; Matthew L. Senjem; Keith A. Josephs

doi:10.1212/01.wnl.0000191395.69438.12

Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration

Jennifer L. Whitwell, Clifford R. Jack, Matthew L. Senjem, Keith A. Josephs

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68 Scopus citations

Abstract

The authors used voxel-based morphometry to compare the patterns of brain atrophy in two variants of pathologically confirmed frontotemporal lobar degeneration (FTLD): FTLD with motor neuron disease (FTLD-MND) and FTLD with ubiquitin-only-immunoreactive neuronal changes (FTLD-U). Patterns of atrophy were distinct and different from each other. A localized pattern of frontal lobe atrophy was found in FTLD-MND with a more wide-spread pattern of atrophy affecting the frontal and temporal lobes in FTLD-U.

Original language	English (US)
Pages (from-to)	102-104
Number of pages	3
Journal	Neurology
Volume	66
Issue number	1
DOIs	https://doi.org/10.1212/01.wnl.0000191395.69438.12
State	Published - Jan 2006

ASJC Scopus subject areas

Clinical Neurology

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AB - The authors used voxel-based morphometry to compare the patterns of brain atrophy in two variants of pathologically confirmed frontotemporal lobar degeneration (FTLD): FTLD with motor neuron disease (FTLD-MND) and FTLD with ubiquitin-only-immunoreactive neuronal changes (FTLD-U). Patterns of atrophy were distinct and different from each other. A localized pattern of frontal lobe atrophy was found in FTLD-MND with a more wide-spread pattern of atrophy affecting the frontal and temporal lobes in FTLD-U.

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Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration

Abstract

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