Pathophysiology of Progression: Organ and Cellular Considerations

Anupam Agarwal, Karl A Nath

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


A steady functional decline in surviving nephrons and increasing nephron dropout underlie the progression of chronic kidney disease (CKD). A concept common to all mechanisms implicated in the progression of CKD is that processes centered in a particular renal compartment [en dash] glomerular, tubular, interstitial, vascular [en dash] recruit injurious processes in others, and it is this increasing recruitment and interplay of diverse pathobiologic processes, involving multiple renal compartments, that underlie progressive CKD. This chapter reviews these processes and their interaction in the progression of CKD, along with the role of specific mediators and inhibitors of CKD.

Original languageEnglish (US)
Title of host publicationChronic Renal Disease
PublisherElsevier Inc.
Number of pages15
ISBN (Print)9780124116160, 9780124116023
StatePublished - Sep 24 2014


  • Chronic kidney disease
  • Growth factors
  • Oxidative stress
  • Proteinuria
  • Renin-angiotensin

ASJC Scopus subject areas

  • General Medicine


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