Pathophysiology of Portal Hypertension and Its Clinical Links

Yeon Seok Seo, Vijay H. Shah

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Portal hypertension is a major cause of morbidity and mortality in patients with liver cirrhosis. Intrahepatic vascular resistance due to architectural distortion and intrahepatic vasoconstriction, increased portal blood flow due to splanchnic vasodilatation, and development of collateral circulation have been considered as major factors for the development of portal hypertension. Recently, sinusoidal remodeling and angiogenesis have been focused as potential etiologic factors and various researchers have tried to improve portal hypertension by modulating these new targets. This article reviews potential new treatments in the context of portal hypertension pathophysiology concepts.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalJournal of Clinical and Experimental Hepatology
Issue number2
StatePublished - Sep 2011


  • Angiogenesis
  • Pathophysiology
  • Portal hypertension
  • Sinusoids
  • Treatment

ASJC Scopus subject areas

  • Hepatology


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