Pathology of demyelinating diseases

Bogdan F.Gh Popescu, Claudia F. Lucchinetti

Research output: Contribution to journalReview articlepeer-review

193 Scopus citations


There has been significant progress in our understanding of the pathology and pathogenesis of central nervous system inflammatory demyelinating diseases. Neuropathological studies have provided fundamental new insights into the pathogenesis of these disorders and have led to major advances in our understanding of multiple sclerosis (MS) heterogeneity, the substrate of irreversible progressive disability in MS, the relationship between inflammation and neurodegeneration in MS, the neuroimaging correlates of MS lesions, and the pathogenesis of other central nervous system inflammatory disorders, including neuromyelitis optica, acute disseminated encephalomyelitis, and Balo's concentric sclerosis. Herein, we review the pathological features of these central nervous system inflammatory demyelinating disorders and discuss neuropathological studies that have yielded novel insights into potential mechanisms involved in the formation of the demyelinated lesion.

Original languageEnglish (US)
Pages (from-to)185-217
Number of pages33
JournalAnnual Review of Pathology: Mechanisms of Disease
StatePublished - 2012


  • Acute disseminated encephalomyelitis
  • Acute hemorrhagic leukoencephalitis
  • Balo's concentric sclerosis
  • Marburg disease
  • Multiple sclerosis
  • Neuromyelitis optica

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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