Pathological fractures in primary bone sarcomas

Panayiotis J. Papagelopoulos, Andreas F. Mavrogenis, Olga D. Savvidou, Ioannis S. Benetos, Evanthia C. Galanis, Panayotis N. Soucacos

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Pathological fractures in patients with primary bone sarcomas should not be considered an absolute indication for amputation. Initial fracture management should include cast immobilisation or external fixation avoiding tumour-cell dissemination. The extent of fracture displacement and the type of fracture stabilisation may affect the outcome of patients with primary bone sarcomas presenting with pathological fractures. Patients with high-grade primary bone sarcomas should be treated by neo-adjuvant chemotherapy, and limb-salvage surgery. Pathological fractures in chemo-resistant primary bone sarcomas are a relative contraindication for limb salvage surgery.

Original languageEnglish (US)
Pages (from-to)395-403
Number of pages9
Issue number4
StatePublished - Apr 2008


  • Bone sarcomas
  • Chemotherapy
  • Ewing's sarcoma
  • Limb salvage
  • Megaprosthesis
  • Osteosarcoma
  • Pathological fractures
  • Radiation therapy

ASJC Scopus subject areas

  • Emergency Medicine
  • Orthopedics and Sports Medicine


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