Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity

Satoko Yamaoka, Hideki Ebihara

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus, causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%. While there have been six virus species classified, which each have a single type virus in the genus Ebolavirus, CFRs of ebolavirus infections vary among viruses belonging to each distinct species. In this review, we aim to define the ebolavirus species-specific virulence on the basis of currently available laboratory and experimental findings. In addition, this review will also cover the variant-specific virulence of EBOV by referring to the unique biological and pathogenic characteristics of EBOV variant Makona, a new EBOV variant isolated from the 2013–2016 EBOV disease outbreak in West Africa. A better definition of species-specific and variant-specific virulence of ebolaviruses will facilitate our comprehensive knowledge on genus Ebolavirus biology, leading to the development of therapeutics against well-focused pathogenic mechanisms of each Ebola disease.

Original languageEnglish (US)
Pages (from-to)885-901
Number of pages17
Issue number1
StatePublished - 2021


  • Bundibugyo virus
  • Ebola virus
  • Reston virus
  • Sudan virus
  • Taï Forest virus
  • case fatality rates
  • virulence

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases


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