Pathogenesis of varicose veins

Rahmi Oklu, Roy Habito, Manuel Mayr, Amy R. Deipolyi, Hassan Albadawi, Robin Hesketh, T. Gregory Walker, Katy R. Linskey, Chandler A. Long, Stephan Wicky, Julianne Stoughton, Michael T. Watkins

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Despite the high prevalence of varicose veins and the recent surge in research on the condition, the precise mechanisms underlying their development remain uncertain. In the past decade, there has been a shift from initial theories based on purely mechanical factors to hypotheses pointing to complex molecular changes causing histologic alterations in the vessel wall and extracellular matrix. Despite progress in understanding the molecular aspects of venous insufficiency, therapies for symptomatic varicose veins are directed toward anatomic and physical interventions. The present report reviews current evidence identifying the underlying biochemical alterations in the pathogenesis of varicose veins.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Issue number1
StatePublished - Jan 2012

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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