Paravalvular Leak in Structural Heart Disease

Kashish Goel, Mackram Eleid

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Purpose of Review: This review will summarize the growing importance of diagnosing and managing paravalvular leak associated with surgical and transcatheter valves. Recent Findings: The burden of paravalvular leak is increasing; however, advanced imaging techniques and high degree of clinical suspicion are required for diagnosis and management. The latest data from pivotal clinical trials in the field of transcatheter aortic valve replacement suggest that any paravalvular leak greater than mild was associated with worse clinical outcomes. Percutaneous techniques for paravalvular leak closure are now the preferred approach, and surgical repair is reserved for contraindications and unsuccessful procedures. Recent data from studies evaluating paravalvular leak closure outcomes report a greater than 90% success rate with a significant improvement in patient symptoms. Summary: Paravalvular leak is a growing problem in the structural heart disease arena. Percutaneous closure is successful in more than 90% of the procedures with a low complication rate.

Original languageEnglish (US)
Article number18
JournalCurrent cardiology reports
Issue number3
StatePublished - Mar 1 2018


  • Closure
  • Hemolysis
  • Paravalvular leak
  • Structural
  • Valvular heart disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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