Parathyroid hormone and calcium a relationship in hypertension

Prince K. Zachariah, Gary L. Schwartz, Cameron G. Strong, Stephen G. Ritter

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Total and ionized calcium, parathyroid hormone, calcitonin, and renin activity were measured in 27 untreated patients with essential hypertension. There was no relationship between any of these parameters and diastolic blood pressure. However, a significant inverse relationship was found between diastolic blood pressure and the ratio of either total or ionized calcium to parathyroid hormone (r = —0.40, P < 0.05; and r = —0.38, P < 0.05, respectively). The ratios did not correlate with patient age or plasma renin level. This preliminary finding suggests that the role of plasma calcium in hypertension may need to be analyzed in the context of overall calcium metabolism, as influenced by the parathyroid hormone. The role of an altered relationship between plasma calcium level and parathyroid hormone in the pathophysiology of essential hypertension remains to be studied. Am J Hypertens 1988;1:79S-82S.

Original languageEnglish (US)
Pages (from-to)79S-82S
JournalAmerican journal of hypertension
Issue number3
StatePublished - Jul 1988


  • Calcitonin
  • Calcium
  • Diastolic blood pressure
  • Essential hypertension
  • Parathyroid hormone

ASJC Scopus subject areas

  • Internal Medicine


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