Paraneoplastic motor neuron disease with type 1 Purkinje cell antibodies

Shamsuddin Khwaja, Naganand Sripathi, B. K. Ahmad, Vanda A. Lennon

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Autoimmune serological testing is a useful aid for identifying a paraneoplastic basis for sporadic motor neuron disease. A 67-year-old woman with ovarian carcinoma presented with progressive weakness. Neurological examination was suggestive of motor neuron disease with signs of upper motor neuron disorder. Electromyography revealed severe motor neuronopathy of the upper extremities. Characteristic type 1 Purkinje cell antibodies (anti-Yo antibody) was detected in the serum diluted at 1:61,400.

Original languageEnglish (US)
Pages (from-to)943-945
Number of pages3
JournalMuscle and Nerve
Issue number7
StatePublished - Jul 1998


  • Anti-Yo
  • Motor neuron disease
  • Ovarian cancer
  • Paraneoplastic
  • Type 1 Purkinje cell antibodies

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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