Pancreatic Disorders in Patients with Inflammatory Bowel Disease

Marilia L. Montenegro, Juan E. Corral, Frank J. Lukens, Baoan Ji, Paul T. Kröner, Francis A. Farraye, Yan Bi

Research output: Contribution to journalReview articlepeer-review


Inflammatory bowel disease (IBD) can involve multiple organ systems, and pancreatic manifestations of IBD are not uncommon. The incidence of several pancreatic diseases is more frequent in patients with Crohn’s disease and ulcerative colitis than in the general population. Pancreatic manifestations in IBD include a heterogeneous group of disorders and abnormalities ranging from mild, self-limited disorders to severe diseases. Asymptomatic elevation of amylase and/or lipase is common. The risk of acute pancreatitis in patients with IBD is increased due to the higher incidence of cholelithiasis and drug-induced pancreatitis in this population. Patients with IBD commonly have altered pancreatic histology and chronic pancreatic exocrine dysfunction. Diagnosing acute pancreatitis in patients with IBD is challenging. In this review, we discuss the manifestations and possible causes of pancreatic abnormalities in patients with IBD.

Original languageEnglish (US)
Pages (from-to)423-436
Number of pages14
JournalDigestive diseases and sciences
Issue number2
StatePublished - Feb 2022


  • Crohn’s disease
  • Extraintestinal manifestations
  • Inflammatory bowel disease
  • Pancreatitis
  • Ulcerative colitis

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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