Pancreatic Cystic Neoplasms: Translating Guidelines into Clinical Practice

Sonmoon Mohapatra, Somashekar G. Krishna, Rahul Pannala

Research output: Contribution to journalReview articlepeer-review


A combination of several factors, including the increasing use of cross-sectional imaging and an aging population, has led to pancreatic cystic lesions (PCLs) becoming the most detected incidental pancreatic lesions. Accurate diagnosis and risk stratification of PCLs is challenging. In the last decade, several evidence-based guidelines have been published addressing the diagnosis and management of PCLs. However, these guidelines cover different subsets of patients with PCLs and offer varying recommendations regarding diagnostic assessment, surveillance, and surgical resection. Further, recent studies comparing the accuracy of various guidelines have reported significant variations in the rate of missed cancer versus unnecessary surgical resections. In clinical practice, it is challenging to decide which guideline to follow specifically. This article reviews the varying recommendations of the major guidelines and results of comparative studies, provides an overview of newer modalities not included in the guidelines, and offers perspectives on translating the guidelines into clinical practice.

Original languageEnglish (US)
Article number749
Issue number4
StatePublished - Feb 2023


  • branched duct intraductal papillary mucinous neoplasms
  • guidelines
  • main duct intraductal papillary mucinous neoplasms
  • mucinous cystic neoplasm
  • pancreatic cancer
  • pancreatic cystic lesions
  • serous cystic neoplasm

ASJC Scopus subject areas

  • Clinical Biochemistry


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