TY - JOUR
T1 - Paired-Associative Stimulation-Induced Long-term Potentiation-Like Motor Cortex Plasticity in Healthy Adolescents
AU - Lee, Jonathan C.
AU - Croarkin, Paul E.
AU - Ameis, Stephanie H.
AU - Sun, Yinming
AU - Blumberger, Daniel M.
AU - Rajji, Tarek K.
AU - Daskalakis, Zafiris J.
N1 - Funding Information:
Funding. JL received funding through the Canadian Psychiatric Association Scotiabank Grant for Children and Mental Health and the Chisholm Memorial Fellowship from the University of Toronto.
Publisher Copyright:
Copyright © 2017 Lee, Croarkin, Ameis, Sun, Blumberger, Rajji and Daskalakis.
PY - 2017/5/29
Y1 - 2017/5/29
N2 - Objective: The objective of this study was to evaluate the feasibility of using paired-associative stimulation (PAS) to study excitatory and inhibitory plasticity in adolescents while examining variables that may moderate plasticity (such as sex and environment). Methods: We recruited 34 healthy adolescents (aged 13–19, 13 males, 21 females). To evaluate excitatory plasticity, we compared mean motor-evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS) before and after PAS at 0, 15, and 30 min. To evaluate inhibitory plasticity, we evaluated the cortical silent period (CSP) elicited by single-pulse TMS in the contracted hand before and after PAS at 0, 15, and 30 min. Results: All participants completed PAS procedures. No adverse events occurred. PAS was well tolerated. PAS-induced significant increases in the ratio of post-PAS MEP to pre-PAS MEP amplitudes (p < 0.01) at all post-PAS intervals. Neither socioeconomic status nor sex was associated with post-PAS MEP changes. PAS induced significant CSP lengthening in males but not females. Conclusion: PAS is a feasible, safe, and well-tolerated index of adolescent motor cortical plasticity. Gender may influence PAS-induced changes in cortical inhibition. PAS is safe and well tolerated by healthy adolescents and may be a novel tool with which to study adolescent neuroplasticity.
AB - Objective: The objective of this study was to evaluate the feasibility of using paired-associative stimulation (PAS) to study excitatory and inhibitory plasticity in adolescents while examining variables that may moderate plasticity (such as sex and environment). Methods: We recruited 34 healthy adolescents (aged 13–19, 13 males, 21 females). To evaluate excitatory plasticity, we compared mean motor-evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS) before and after PAS at 0, 15, and 30 min. To evaluate inhibitory plasticity, we evaluated the cortical silent period (CSP) elicited by single-pulse TMS in the contracted hand before and after PAS at 0, 15, and 30 min. Results: All participants completed PAS procedures. No adverse events occurred. PAS was well tolerated. PAS-induced significant increases in the ratio of post-PAS MEP to pre-PAS MEP amplitudes (p < 0.01) at all post-PAS intervals. Neither socioeconomic status nor sex was associated with post-PAS MEP changes. PAS induced significant CSP lengthening in males but not females. Conclusion: PAS is a feasible, safe, and well-tolerated index of adolescent motor cortical plasticity. Gender may influence PAS-induced changes in cortical inhibition. PAS is safe and well tolerated by healthy adolescents and may be a novel tool with which to study adolescent neuroplasticity.
KW - adolescent psychiatry
KW - cortical silent period
KW - developmental neuroplasticity
KW - motor cortical plasticity
KW - motor-evoked potentials
KW - paired-associative stimulation
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U2 - 10.3389/fpsyt.2017.00095
DO - 10.3389/fpsyt.2017.00095
M3 - Article
AN - SCOPUS:85059350108
SN - 1664-0640
VL - 8
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
M1 - 95
ER -