Outcomes of Ultrasound-Guided Thrombin Injection of Nongroin Arterial Pseudoaneurysms

Johnathan C. Valesano, John J. Schmitz, A. Nicholas Kurup, Grant D. Schmit, Michael R. Moynagh, Thomas D. Atwell, Bradley D. Lewis, Robert A. Lee, Matthew R. Callstrom

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Purpose To evaluate success and complication rates of percutaneous ultrasound-guided thrombin injection of nongroin pseudoaneurysms (PSAs). Materials and Methods Retrospective review of a prospectively maintained institutional database yielded 39 cases of arterial PSAs occurring at nongroin sites that were treated with percutaneous ultrasound-guided thrombin injection between 2000 and 2016 (average patient age 69.2 y ± 14.0). Of PSAs, 74.4% (29/39) arose in the upper extremities, and 92.3% (36/39) were iatrogenic. The brachial artery was the most commonly affected vessel (51.3% [20/39]), and arterial access was the most common cause (56.4% [22/39]). Average overall PSA size was 2.4 cm (range, 0.5–7.2 cm); average amount of thrombin injected was 320 IU (range, 50–2,000 IU). Technical success was defined as absence of flow within the PSA immediately after thrombin injection. Treatment success was defined as sustained thrombosis on follow-up imaging obtained at 1–3 days after treatment. Results Technical and treatment success rates of thrombin injections were 100% (39/39) and 84.8% (28/33), respectively. Longer term follow-up imaging (average 71 d; range, 12–201 d) was available for 7 of the treatment successes with 100% (7/7) showing sustained thrombosis. Comparing treatment successes and failures, there was no significant difference in average PSA size (2.3 cm vs 2.0 cm, P =.51) or average amount of thrombin injected (360 IU vs 180 IU, P =.14). There were no complications. Conclusions Ultrasound-guided thrombin injection is a safe, efficacious treatment option for PSAs arising in nongroin locations.

Original languageEnglish (US)
Pages (from-to)1156-1160
Number of pages5
JournalJournal of Vascular and Interventional Radiology
Issue number8
StatePublished - Aug 2017

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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