Outcome of critically ill patients with influenza virus infection

Guangxi Li, Murat Yilmaz, Marija Kojicic, Evans Fernández-Pérez, Raed Wahab, W. Charles Huskins, Bekele Afessa, Jonathon D. Truwit, Ognjen Gajic

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Background: Influenza is a major cause of morbidity and mortality, with its greatest burden on the elderly and patients with chronic co-morbidities in the intensive care unit (ICU). An accurate prognosis is essential for decision-making during pandemic as well as interpandemic periods. Methods: A retrospective cohort study was conducted to determine prognostic factors influencing short term outcome of critically ill patients with confirmed influenza virus infection. Baseline characteristics, laboratory and diagnostic findings, ICU interventions and complications were abstracted from medical records using standard definitions and compared between hospital survivors and non-survivors with univariate and multivariate logistic regression analyses. Results: 111 patients met the inclusion criteria. Acute respiratory distress syndrome (ARDS) complicated ICU course in 25 (23%) of the patients, with mortality rate of 52%. Multivariate logistic regression analysis identified the following predictors of hospital mortality: Acute Physiology and Chronic Health Evaluation (APACHE) III predicted mortality (Odds ratio [OR] 1.49, 95% confidence interval [CI] 1.1-2.1 for 10% increase), ARDS (OR 7.7, 95% CI 2.3-29) and history of immunosuppression (OR 7.19, 95% CI 1.9-28). Conclusions: APACHE III predicted mortality, the development of ARDS and the history of immunosuppression are independent risk factors for hospital mortality in critically ill patients with confirmed influenza virus infection.

Original languageEnglish (US)
Pages (from-to)275-278
Number of pages4
JournalJournal of Clinical Virology
Issue number3
StatePublished - Nov 2009


  • Human
  • ICUs
  • Influenza
  • Outcome Assessment
  • Prognosis

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


Dive into the research topics of 'Outcome of critically ill patients with influenza virus infection'. Together they form a unique fingerprint.

Cite this