Bree R. Eaton, Rudolf Schwarz, Ralph Vatner, Brian Yeh, Line Claude, Daniel J. Indelicato, Nadia Laack

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Osteosarcoma is a rare tumor that requires complex multidisciplinary management. This paper reviews the general management and standard radiotherapy guidelines for osteosarcoma in both North America and Europe in a joined effort between the Children's Oncology Group and International Society of Pediatric Oncology. Standard treatment involves multiagent induction chemotherapy followed by surgical resection for local tumor control and consolidation local control to metastatic sites. Radiotherapy is reserved for cases with a marginal or incomplete resection or for definitive treatment in the case of unresectable disease. We present supporting data for the role of chemotherapy, surgery, and radiation therapy.

Original languageEnglish (US)
Article numbere28352
JournalPediatric Blood and Cancer
Issue numberS2
StatePublished - May 2021


  • chemotherapy
  • metastasis
  • osteosarcoma
  • radiotherapy
  • surgery

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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