Organ Failure Due to Systemic Injury in Acute Pancreatitis

Parmod K. Garg, Vijay P. Singh

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Acute pancreatitis may be associated with both local and systemic complications. Systemic injury manifests in the form of organ failure, which is seen in approximately 20% of all cases of acute pancreatitis and defines “severe acute pancreatitis.” Organ failure typically develops early in the course of acute pancreatitis, but also may develop later due to infected pancreatic necrosis–induced sepsis. Organ failure is the most important determinant of outcome in acute pancreatitis. We review here the current understanding of the risk factors, pathophysiology, timing, impact on outcome, and therapy of organ failure in acute pancreatitis. As we discuss the pathophysiology of severe systemic injury, the distinctions between markers and mediators of severity are highlighted based on evidence supporting their causality in organ failure. Emphasis is placed on clinically relevant end points of organ failure and the mechanisms underlying the pathophysiological perturbations, which offer insight into potential therapeutic targets to treat.

Original languageEnglish (US)
Pages (from-to)2008-2023
Number of pages16
Issue number7
StatePublished - May 2019


  • Acute Pancreatitis
  • Organ Failure
  • Pathophysiology

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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