Optimal use of intranasal corticosteroids and intranasal saline, is there a clear answer?

Catherine M. Freeman, Matthew A. Rank

Research output: Contribution to journalReview articlepeer-review


Purpose of reviewChronic rhinosinusitis (CRS) is a prevalent condition that poses a significant burden on both quality of life and healthcare utilization. Notwithstanding the heterogenous nature of CRS endotypes and phenotypes, isotonic saline and corticosteroids are recommended as first line medical therapy by recent clinical guidelines. We provide an overview of recent studies of topical saline and corticosteroids for people with CRS and emphasize areas of unmet needs.Recent findingsRecent trials suggest exhalation delivery systems of corticosteroid are effective and well tolerated but did not involve comparison with another active treatment. Recent comparative efficacy studies show no clear differences in doses of topical corticosteroid, method of topical corticosteroid delivery, advantage over macrolide antibiotic, or method or type of saline irrigation.SummaryThe preeminent formulation, dosage, and delivery of topical corticosteroid and saline for people with CRS represents an area of ongoing research need.

Original languageEnglish (US)
Pages (from-to)394-400
Number of pages7
JournalCurrent Opinion in Allergy and Clinical Immunology
Issue number4
StatePublished - Aug 1 2021


  • chronic rhinosinusitis
  • corticosteroids
  • exhalation delivery system
  • medical management
  • saline
  • saline adjuncts
  • therapeutic strategies
  • topical steroids

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Optimal use of intranasal corticosteroids and intranasal saline, is there a clear answer?'. Together they form a unique fingerprint.

Cite this