Opioid-Induced Adrenal Insufficiency

Diane Donegan; Irina Bancos

doi:10.1016/j.mayocp.2018.04.010

Opioid-Induced Adrenal Insufficiency

Diane Donegan, Irina Bancos

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

One in 10 Americans experience chronic pain. Although opioids do play a role in the management of pain, long-term opioid use may lead to adverse effects. Endocrine-related adverse effects have been described but remain poorly recognized. Opioid-induced adrenal insufficiency occurs because of suppression of hypothalamic-pituitary-adrenal communication and may be challenging to diagnose but has been reported in 9% to 29% of patients receiving long-term opiate therapy. Little data exist to guide case detection and patient management. Treatment includes cessation of opiates (the inciting factor) if possible and glucocorticoid replacement.

Original language	English (US)
Pages (from-to)	937-944
Number of pages	8
Journal	Mayo Clinic proceedings
Volume	93
Issue number	7
DOIs	https://doi.org/10.1016/j.mayocp.2018.04.010
State	Published - Jul 2018

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/j.mayocp.2018.04.010

Cite this

@article{1ad66dae3d7d4cea87b66148bc6a7326,

title = "Opioid-Induced Adrenal Insufficiency",

abstract = "One in 10 Americans experience chronic pain. Although opioids do play a role in the management of pain, long-term opioid use may lead to adverse effects. Endocrine-related adverse effects have been described but remain poorly recognized. Opioid-induced adrenal insufficiency occurs because of suppression of hypothalamic-pituitary-adrenal communication and may be challenging to diagnose but has been reported in 9\% to 29\% of patients receiving long-term opiate therapy. Little data exist to guide case detection and patient management. Treatment includes cessation of opiates (the inciting factor) if possible and glucocorticoid replacement.",

author = "Diane Donegan and Irina Bancos",

note = "Publisher Copyright: {\textcopyright} 2018 Mayo Foundation for Medical Education and Research",

year = "2018",

month = jul,

doi = "10.1016/j.mayocp.2018.04.010",

language = "English (US)",

volume = "93",

pages = "937--944",

journal = "Mayo Clinic proceedings",

issn = "0025-6196",

publisher = "Elsevier Ltd",

number = "7",

}

TY - JOUR

T1 - Opioid-Induced Adrenal Insufficiency

AU - Donegan, Diane

AU - Bancos, Irina

PY - 2018/7

Y1 - 2018/7

N2 - One in 10 Americans experience chronic pain. Although opioids do play a role in the management of pain, long-term opioid use may lead to adverse effects. Endocrine-related adverse effects have been described but remain poorly recognized. Opioid-induced adrenal insufficiency occurs because of suppression of hypothalamic-pituitary-adrenal communication and may be challenging to diagnose but has been reported in 9% to 29% of patients receiving long-term opiate therapy. Little data exist to guide case detection and patient management. Treatment includes cessation of opiates (the inciting factor) if possible and glucocorticoid replacement.

AB - One in 10 Americans experience chronic pain. Although opioids do play a role in the management of pain, long-term opioid use may lead to adverse effects. Endocrine-related adverse effects have been described but remain poorly recognized. Opioid-induced adrenal insufficiency occurs because of suppression of hypothalamic-pituitary-adrenal communication and may be challenging to diagnose but has been reported in 9% to 29% of patients receiving long-term opiate therapy. Little data exist to guide case detection and patient management. Treatment includes cessation of opiates (the inciting factor) if possible and glucocorticoid replacement.

UR - https://www.scopus.com/pages/publications/85048943337

UR - https://www.scopus.com/inward/citedby.url?scp=85048943337&partnerID=8YFLogxK

U2 - 10.1016/j.mayocp.2018.04.010

DO - 10.1016/j.mayocp.2018.04.010

M3 - Review article

AN - SCOPUS:85048943337

SN - 0025-6196

VL - 93

SP - 937

EP - 944

JO - Mayo Clinic proceedings

JF - Mayo Clinic proceedings

IS - 7

ER -

Opioid-Induced Adrenal Insufficiency

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this