Oncolytic Reovirus-Mediated Recruitment of Early Innate Immune Responses Reverses Immunotherapy Resistance in Prostate Tumors

Nicola E. Annels; Guy R. Simpson; Mick Denyer; Mehreen Arif; Matt Coffey; Alan Melcher; Kevin Harrington; Richard Vile; Hardev Pandha

doi:10.1016/j.omto.2020.09.010

Oncolytic Reovirus-Mediated Recruitment of Early Innate Immune Responses Reverses Immunotherapy Resistance in Prostate Tumors

Nicola E. Annels
, Guy R. Simpson
, Mick Denyer
, Mehreen Arif
, Matt Coffey
, Alan Melcher
, Kevin Harrington
, Richard Vile
, Hardev Pandha

Molecular Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Immunotherapy in prostate cancer is limited because of a lack of immune cells within the tumor. Annels et al. used oncolytic viruses to recruit immune cells into the tumor and showed that in combination with checkpoint inhibitors, which take the brake off of the immune system, established tumors were rejected.

Original language	English (US)
Pages (from-to)	434-446
Number of pages	13
Journal	Molecular Therapy Oncolytics
Volume	20
DOIs	https://doi.org/10.1016/j.omto.2020.09.010
State	Published - Mar 26 2021

Keywords

Immunotherapy resistance
Oncolytic virus
Prostate cancer

ASJC Scopus subject areas

Molecular Medicine
Oncology
Cancer Research
Pharmacology (medical)

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10.1016/j.omto.2020.09.010

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title = "Oncolytic Reovirus-Mediated Recruitment of Early Innate Immune Responses Reverses Immunotherapy Resistance in Prostate Tumors",

abstract = "Immunotherapy in prostate cancer is limited because of a lack of immune cells within the tumor. Annels et al. used oncolytic viruses to recruit immune cells into the tumor and showed that in combination with checkpoint inhibitors, which take the brake off of the immune system, established tumors were rejected.",

keywords = "Immunotherapy resistance, Oncolytic virus, Prostate cancer",

author = "Annels, \{Nicola E.\} and Simpson, \{Guy R.\} and Mick Denyer and Mehreen Arif and Matt Coffey and Alan Melcher and Kevin Harrington and Richard Vile and Hardev Pandha",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2021",

month = mar,

day = "26",

doi = "10.1016/j.omto.2020.09.010",

language = "English (US)",

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journal = "Molecular Therapy Oncolytics",

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TY - JOUR

T1 - Oncolytic Reovirus-Mediated Recruitment of Early Innate Immune Responses Reverses Immunotherapy Resistance in Prostate Tumors

AU - Annels, Nicola E.

AU - Simpson, Guy R.

AU - Denyer, Mick

AU - Arif, Mehreen

AU - Coffey, Matt

AU - Melcher, Alan

AU - Harrington, Kevin

AU - Vile, Richard

AU - Pandha, Hardev

PY - 2021/3/26

Y1 - 2021/3/26

N2 - Immunotherapy in prostate cancer is limited because of a lack of immune cells within the tumor. Annels et al. used oncolytic viruses to recruit immune cells into the tumor and showed that in combination with checkpoint inhibitors, which take the brake off of the immune system, established tumors were rejected.

AB - Immunotherapy in prostate cancer is limited because of a lack of immune cells within the tumor. Annels et al. used oncolytic viruses to recruit immune cells into the tumor and showed that in combination with checkpoint inhibitors, which take the brake off of the immune system, established tumors were rejected.

KW - Immunotherapy resistance

KW - Oncolytic virus

KW - Prostate cancer

UR - https://www.scopus.com/pages/publications/85100736301

UR - https://www.scopus.com/pages/publications/85100736301#tab=citedBy

U2 - 10.1016/j.omto.2020.09.010

DO - 10.1016/j.omto.2020.09.010

M3 - Article

AN - SCOPUS:85100736301

SN - 2372-7705

VL - 20

SP - 434

EP - 446

JO - Molecular Therapy Oncolytics

JF - Molecular Therapy Oncolytics

ER -

Oncolytic Reovirus-Mediated Recruitment of Early Innate Immune Responses Reverses Immunotherapy Resistance in Prostate Tumors

Abstract

Keywords

ASJC Scopus subject areas

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