On the brink of becoming a T cell

Christine Borowski, Colin Martin, Fotini Gounari, Loralee Haughn, Iannis Aifantis, Fabio Grassi, Harald Von Boehmer

Research output: Contribution to journalReview articlepeer-review


Recent studies provide fresh insight into the mechanisms by which precursor cells are committed to and develop within the T-lymphocyte lineage. Precursor/product studies have identified developmental stages between that of the pluripotent hematopoietic stem cell and thymocytes committed to the T lineage. Specific ligands and signaling pathways interacting with the Notch-1 receptor and its ability to influence commitment within the lymphoid lineage have been described. Although the structural features or putative ligands endowing the pre-TCR with constitutive signaling capacity remain elusive, numerous distal mediators of pre-TCR signaling have been identified. It remains for the future to determine what roles they may have in survival, proliferation, lineage commitment and allelic exclusion of TCR genes. Receptor editing and lineage commitment of αβ T cells still represent controversial topics that need further study.

Original languageEnglish (US)
Pages (from-to)200-206
Number of pages7
JournalCurrent Opinion in Immunology
Issue number2
StatePublished - Apr 1 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'On the brink of becoming a T cell'. Together they form a unique fingerprint.

Cite this