Obstacles to translating genotype-phenotype correlates in metabolic disease

Anu Sharma; Adrian Vella

doi:10.1152/physiol.00009.2016

Obstacles to translating genotype-phenotype correlates in metabolic disease

Anu Sharma, Adrian Vella

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Type 2 diabetes mellitus is a polygenic disease with a variable phenotype. Many genetic associations have been described; however, understanding their underlying pathophysiological role in Type 2 diabetes mellitus is important for development of future therapeutic targets. Here, we review the physiological mechanisms of diabetes-associated variants that affect glycemia.

Original language	English (US)
Pages (from-to)	42-50
Number of pages	9
Journal	Physiology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1152/physiol.00009.2016
State	Published - Jan 2017

ASJC Scopus subject areas

Physiology

Access to Document

10.1152/physiol.00009.2016

Cite this

@article{7393a7b920f647fe8ad5ce0ce6257578,

title = "Obstacles to translating genotype-phenotype correlates in metabolic disease",

abstract = "Type 2 diabetes mellitus is a polygenic disease with a variable phenotype. Many genetic associations have been described; however, understanding their underlying pathophysiological role in Type 2 diabetes mellitus is important for development of future therapeutic targets. Here, we review the physiological mechanisms of diabetes-associated variants that affect glycemia.",

author = "Anu Sharma and Adrian Vella",

note = "Publisher Copyright: {\textcopyright} 2017 Int. Union Physiol. Sci./Am. Physiol. Soc.",

year = "2017",

month = jan,

doi = "10.1152/physiol.00009.2016",

language = "English (US)",

volume = "32",

pages = "42--50",

journal = "Physiology",

issn = "1548-9213",

publisher = "American Physiological Society",

number = "1",

}

TY - JOUR

T1 - Obstacles to translating genotype-phenotype correlates in metabolic disease

AU - Sharma, Anu

AU - Vella, Adrian

PY - 2017/1

Y1 - 2017/1

N2 - Type 2 diabetes mellitus is a polygenic disease with a variable phenotype. Many genetic associations have been described; however, understanding their underlying pathophysiological role in Type 2 diabetes mellitus is important for development of future therapeutic targets. Here, we review the physiological mechanisms of diabetes-associated variants that affect glycemia.

AB - Type 2 diabetes mellitus is a polygenic disease with a variable phenotype. Many genetic associations have been described; however, understanding their underlying pathophysiological role in Type 2 diabetes mellitus is important for development of future therapeutic targets. Here, we review the physiological mechanisms of diabetes-associated variants that affect glycemia.

UR - https://www.scopus.com/pages/publications/85005963639

UR - https://www.scopus.com/inward/citedby.url?scp=85005963639&partnerID=8YFLogxK

U2 - 10.1152/physiol.00009.2016

DO - 10.1152/physiol.00009.2016

M3 - Review article

C2 - 27927804

AN - SCOPUS:85005963639

SN - 1548-9213

VL - 32

SP - 42

EP - 50

JO - Physiology

JF - Physiology

IS - 1

ER -

Obstacles to translating genotype-phenotype correlates in metabolic disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this