NT69L blocks ethanol-induced increase of dopamine and glutamate levels in striatum of mouse

Zhimin Li; Mona Boules; Elliott Richelson

doi:10.1016/j.neulet.2010.10.048

NT69L blocks ethanol-induced increase of dopamine and glutamate levels in striatum of mouse

Zhimin Li, Mona Boules, Elliott Richelson

Neuroscience

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Recent study shows that NT69L, an analog of neurotensin (NT) (8-13), reduces ethanol consumption and preference in mice through modulation of neurotensin receptor subtype one. The current study showed that NT69L significantly decreased ethanol-induced increase of dopamine and glutamate levels in striatum of mouse. These data suggest that NT69L prevents ethanol consumption through the modulation of both dopaminergic and glutamatergic systems implicated in ethanol addiction. NT agonists may provide novel treatment for alcohol addiction.

Original language	English (US)
Pages (from-to)	322-324
Number of pages	3
Journal	Neuroscience Letters
Volume	487
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2010.10.048
State	Published - Jan 10 2011

Keywords

Dopamine
Ethanol
Glutamate
NT69L
Neurotensin
Striatum

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2010.10.048

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abstract = "Recent study shows that NT69L, an analog of neurotensin (NT) (8-13), reduces ethanol consumption and preference in mice through modulation of neurotensin receptor subtype one. The current study showed that NT69L significantly decreased ethanol-induced increase of dopamine and glutamate levels in striatum of mouse. These data suggest that NT69L prevents ethanol consumption through the modulation of both dopaminergic and glutamatergic systems implicated in ethanol addiction. NT agonists may provide novel treatment for alcohol addiction.",

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author = "Zhimin Li and Mona Boules and Elliott Richelson",

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AU - Boules, Mona

AU - Richelson, Elliott

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N2 - Recent study shows that NT69L, an analog of neurotensin (NT) (8-13), reduces ethanol consumption and preference in mice through modulation of neurotensin receptor subtype one. The current study showed that NT69L significantly decreased ethanol-induced increase of dopamine and glutamate levels in striatum of mouse. These data suggest that NT69L prevents ethanol consumption through the modulation of both dopaminergic and glutamatergic systems implicated in ethanol addiction. NT agonists may provide novel treatment for alcohol addiction.

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KW - Ethanol

KW - Glutamate

KW - NT69L

KW - Neurotensin

KW - Striatum

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NT69L blocks ethanol-induced increase of dopamine and glutamate levels in striatum of mouse

Abstract

Keywords

ASJC Scopus subject areas

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