Novel and emerging nonpositive airway pressure therapies for sleep apnea

John G. Park, Timothy M. Morgenthaler, Peter C. Gay

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


CPAP therapy has remained the standard of care for the treatment of sleep apnea for nearly 4 decades. Its overall effectiveness, however, has been limited by incomplete adherence despite many efforts to improve comfort. Conventional alternative therapies include oral appliances and upper airway surgeries. Recently, several innovative alternatives to CPAP have been developed. These novel approaches include means to increase arousal thresholds, electrical nerve stimulation, oral vacuum devices, and nasal expiratory resistive devices. We will review the physiologic mechanisms and the current evidence for these novel treatments.

Original languageEnglish (US)
Pages (from-to)1946-1952
Number of pages7
Issue number6
StatePublished - Dec 2013

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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