Noninvasive measurement of concurrent single-kidney perfusion, glomerular filtration, and tubular function

James D. Krier, Erik L. Ritman, Zeljko Bajzer, J. Carlos Romero, Amir Lerman, Lilach O. Lerman

Research output: Contribution to journalArticlepeer-review

132 Scopus citations


To assess the reliability of electron beam computed tomography (EBCT), measurements of single-kidney renal blood flow (RBF), glomerular filtration rate (GFR), and intratubular contrast medium concentration (ITC) of radiographic contrast media were quantified in anesthetized pigs before and after acetylcholine-induced vasodilation and diuresis. EBCT measurements were compared with those obtained with intravascular Doppler and inulin clearance. The capability of EBCT to detect chronic changes in single-kidney function was evaluated in pigs with unilateral renal artery stenosis, and their long-term reproducibility in normal pigs was studied repeatedly at 1-mo intervals. EBCT-RBF (ml/min) correlated with Doppler-RBF as RBFEBCT=45+1.07*RBFDoppler, r=0.81. EBCT-GFR (ml/min) correlated with inulin clearance as GFREBCT=11.7+1.02*GFRinulin, r=0.80. During vasodilation, RBF and GFR increased, whereas ITC decreased along the nephron. In renal artery stenosis, single-kidney GFR decreased linearly with the degree of stenosis, and ITC increased along the nephron, indicating increased fluid reabsorption. EBCT-RBF, GFR, and ITC were similar among repeated measurements. This approach might be invaluable for simultaneous quantification of regional hemodynamics and function in the intact kidneys, in a manner potentially applicable to humans.

Original languageEnglish (US)
Pages (from-to)F630-F638
JournalAmerican Journal of Physiology - Renal Physiology
Issue number4 50-4
StatePublished - 2001


  • Electron beam computed tomography
  • Glomerular filtration rate
  • Renal blood flow

ASJC Scopus subject areas

  • Physiology
  • Urology


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