Non-antimicrobial airway management of non-cystic fibrosis bronchiectasis

Ashley M. Egan, Jeremy M. Clain, Patricio Escalante

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Bronchiectasis are often encountered in clinical practice, and are characterized by abnormal airway dilatation and distortion associated with impaired mucociliary clearance and mucous plugging, which are frequently associated with recurrent infections. Numerous etiologies can underlie the development of bronchiectasis, but the most important distinction in research and clinical practice is between bronchiectasis due to cystic fibrosis (CF) and bronchiectasis due to all other reasons (non-CF bronchiectasis). The causes of non-CF bronchiectasis are varied and often unclear. Patients disease severity and phenotypes of non-CF bronchiectasis also varied, which can influence disease trajectory, frequency of exacerbations and mortality. This article reviews the published evidence and suggests interventions to enhance airways clearance in patients with non-CF bronchiectasis, which are key components of an individualized therapeutic program in order to achieve symptomatic relief and prevention of exacerbations and functional decline.

Original languageEnglish (US)
Pages (from-to)24-28
Number of pages5
JournalJournal of Clinical Tuberculosis and Other Mycobacterial Diseases
StatePublished - Jan 2018


  • Airway mucous plugging
  • Bronchiectasis
  • Chest physiotherapy
  • Cystic fibrosis
  • Mucociliary clearance
  • Non-cystic fibrosis bronchiectasis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Microbiology (medical)
  • Infectious Diseases


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