Nicotinic acid adenine dinucleotide phosphate: A new intracellular second messenger?

Eduardo N. Chini, Frederico G.S. De Toledo

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Nicotinic acid adenine dinucleotide phosphate (NAADP) is one of the most potent stimulators of intracellular Ca2+ release known to date. The role of the NAADP system in physiological processes is being extensively investigated at the present time. Exciting new discoveries in the last 5 years suggest that the NAADP-regulated system may have a significant role in intracellular Ca2+ signaling. The NAADP receptor and its associated Ca2+ pool have been hypothesized to be important in several physiological processes including fertilization, T cell activation, and pancreatic secretion. However, whether NAADP is a new second messenger or a tool for the discovery of a new Ca2+ channel is still an unanswered question.

Original languageEnglish (US)
Pages (from-to)C1191-C1198
JournalAmerican Journal of Physiology - Cell Physiology
Issue number6 51-6
StatePublished - 2002


  • Calcium
  • Cyclic adenosine 5′-diphosphate-ribose
  • Endoplasmic reticulum
  • Fertilization
  • Sea urchin eggs

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


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