New therapeutic approaches for hot flashes in women.

Vered Stearns, Charles L. Loprinzi

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


While most women will suffer from hot flashes at some point over their lifetime, most symptoms resolve with time. However, some women may experience severe and/or long-lasting hot flashes. Estrogen, the most effective treatment for hot flashes, is not generally recommended for women with a history of breast cancer or women at high risk of developing breast cancer. Moreover, long-term administration of estrogen to healthy women is associated with increased risks of cardiovascular disease, stroke, and breast cancer. Newer antidepressants from the selective serotonin or noradrenergic reuptake inhibitor family, such as venlafaxine and paroxetine, appear to be among the most effective nonhormonal agents for the treatment of hot flashes. New information demonstrates that gabapentin also is an effective nonhormonal therapy for hot flashes. In this review, we will discuss current knowledge of the epidemiology and pathophysiology of hot flashes, along with treatment options.We will focus on nonhormonal treatments that have been studied in prospective randomized clinical trials, and will present an algorithm for the treatment of symptomatic patients.

Original languageEnglish (US)
Pages (from-to)11-21; discussion 14-15, 19-1521
JournalThe journal of supportive oncology
Issue number1
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)


Dive into the research topics of 'New therapeutic approaches for hot flashes in women.'. Together they form a unique fingerprint.

Cite this