Abstract
Background: KLF14 has elicited attention as a master regulator of lipid metabolism. Results: KLF14 regulates chromatin remodeling on sphingosine kinase 1 gene leading to its activation and sphingosine-1-phosphate production. Conclusion: KLF14 acts as a transcriptional activator for the generation of lipid signaling molecules. Significance: This new knowledge extends the functions assigned to KLF14 and contributes to understanding its role in human diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 15798-15809 |
| Number of pages | 12 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 22 |
| DOIs | |
| State | Published - May 30 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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