Neurotrophin-4/5 promotes proliferation of oligodendrocyte-type-2 astrocytes (O-2A)

Isobel A. Scarisbrick, Kunihiko Asakura, Moses Rodriguez

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


In this study, the ability of neurotrophin-5 (NT-4/5) to promote the proliferation of oligodendrocyte precursor (O-2A) cells has been examined. This has been accomplished by the addition of exogenous NT-4/5 to purified cultures of O-2A cells maintained in an undifferentiated state by the addition of the mitogens platelet derived growth factor (PDGF-AA) and basic fibroblast growth factor (bFGF). Counts of cells incorporating bromodeoxyuridine (BrdU) showed that the addition of NT-4/5 for 24 h increased O-2A cell proliferation by 1.8-fold above that seen in PDGF-AA and bFGF alone. These data demonstrate a previously unidentified role for the neurotrophin NT-4/5 in oligodendrocyte biology. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalDevelopmental Brain Research
Issue number1
StatePublished - Sep 30 2000


  • CNS
  • Development
  • Glia
  • Growth factor
  • Rat

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology


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