Neurotensin: Peptide for the next millennium

Beth M. Tyler-McMahon, Mona Boules, Elliott Richelson

Research output: Contribution to journalReview articlepeer-review

139 Scopus citations


Neurotensin is an endogenous tridecapeptide neurotransmitter (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Try-Ile-Leu-OH) that was discovered by Carraway and Leeman in bovine hypothalami in the early 1970s. Since then this peptide has been the subject of a multitude of articles detailing discoveries related to its activity, receptors, localization, synthesis, and interactions with other systems. This review article does not intend to summarize again all the history of this fascinating peptide and its receptors, since this has been done quite well by others. The reader will be directed to these other reviews, where appropriate. Instead, this review attempts to provide a summary of current knowledge about neurotensin, why it is an important peptide to study, and where the field is heading. Special emphasis is placed on the behavioral studies, particularly with reference to agonists, antagonists, and antisense studies, as well as, the interaction of neurotensin with other neurotransmitters. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)125-136
Number of pages12
JournalRegulatory Peptides
Issue number1-3
StatePublished - Sep 25 2000


  • Agonists
  • Antagonists
  • Antisense studies
  • Behavioral studies
  • Current knowledge
  • Neurotensin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience


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