Neuropathy associated with hyperlipidemia

Philip G. McManis, Anthony J. Windebank, Meral Kiziltan

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


We describe six patients with painful polyneuropathy associated with hyperlipidemia. Each had mild, slowly progressive neuropathycharacterized by pain in feet, without proximal extension or involvement of hands. Weakness and autonomic symptoms and signs were absent. Three patients had normal tendon reflexes; three others had decreased ankle reflexes. Serum cholesterol levels were moderately increased; serum triglyceride levels were exceedingly high. In one patient, symptoms resolved with correction of hypertriglyceridemia. No other cause of peripheral neuropathy was found. Marked increases in serum triglycerides may cause painful small-fiber neuropathy.

Original languageEnglish (US)
Pages (from-to)2185-2186
Number of pages2
Issue number11
StatePublished - Nov 1994

ASJC Scopus subject areas

  • Clinical Neurology


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