Neuromuscular Disorders Associated with Paraproteinemia

Charlene Hoffman-Snyder, Benn E. Smith

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Neuromuscular disorders associated with monoclonal gammopathies are usually uncovered in approximately 10% of patients presenting with peripheral neuropathy complaints. This discovery should prompt further evaluation for underlying plasma cell dyscrasias. The most frequent monoclonal disorders associated with neuropathy are smoldering myeloma, multiple myeloma, Waldenström macroglobulinemia, solitary plasmacytoma, systemic immunoglobulin light chain (AL) amyloidosis, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes), and cryoglobulinemia. If these are excluded by careful evaluation the patient is classified as having monoclonal gammopathy of undetermined significance. Diagnostic criteria, risk stratification to determine prognosis, and current management for these disorders are reviewed in this article.

Original languageEnglish (US)
Pages (from-to)61-79
Number of pages19
JournalPhysical Medicine and Rehabilitation Clinics of North America
Issue number1
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation


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