Neurological complications of melanoma

David Gritsch, Maciej M. Mrugala

Research output: Chapter in Book/Report/Conference proceedingChapter


Malignant melanoma is the fifth most common cancer in men and women. While a majority of patients present with clinically localized disease, brain metastases are found in over one-third of patients with advanced melanoma by the time of diagnosis. In instances when initial therapy is not curative, malignant melanoma will commonly metastasize and produce neurological complications. The treatment of advanced melanoma has traditionally been limited by relative resistance to radiation and cytotoxic chemotherapy. However more recently, the development of molecularly targeted therapy and immunotherapy has led to impressive improvements in outcomes.

Original languageEnglish (US)
Title of host publicationNeurological Complications of Systemic Cancer and Antineoplastic Therapy
Number of pages18
ISBN (Electronic)9780128219768
ISBN (Print)9780128219775
StatePublished - Jan 1 2022


  • Brain metastases
  • Melanoma
  • Neurologic complications
  • Paraneoplastic syndromes
  • Peripheral nerve complications
  • Spinal metastases

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Neurological complications of melanoma'. Together they form a unique fingerprint.

Cite this