TY - JOUR
T1 - Neurological abnormalities in caveolin-1 knock out mice
AU - Trushina, Eugenia
AU - Du Charme, Jordan
AU - Parisi, Joseph
AU - McMurray, Cynthia T.
N1 - Funding Information:
This work was supported by the Mayo Foundation (CTM), Hereditary Disease Foundation (CTM), and National Institutes of Health grants NS40738 (CTM), R01 GM 066359 (CTM). We thank Mr. K. Johnson for help with mouse breeding, and Mr. T. Farnham for help with manuscript preparation.
PY - 2006/9/15
Y1 - 2006/9/15
N2 - Caveolin-1 is the defining structural protein in caveolar vesicles, which regulate signal transduction and cholesterol trafficking in cells. In the brain, cav-1 is highly expressed in neurons and glia, but its function in those cell types is unclear. Mice deficient in cav-1 (CavKO) have been developed to test functional roles for cav-1 in various tissues. However, neurological phenotypes associated with loss of cav-1 in mice have not been evaluated. Here, we report the results of motor and behavioral testing of CavKO mice. We find that mice deficient in cav-1 have reduced brain weight and display a number of motor and behavioral abnormalities. CavKO mice develop neurological phenotypes including clasping, abnormal spinning, muscle weakness, reduced activity, and gait abnormalities. These data suggest that cav-1 is involved in maintaining cortico-striato-pallido-thalamo-pontine pathways associated with motor control.
AB - Caveolin-1 is the defining structural protein in caveolar vesicles, which regulate signal transduction and cholesterol trafficking in cells. In the brain, cav-1 is highly expressed in neurons and glia, but its function in those cell types is unclear. Mice deficient in cav-1 (CavKO) have been developed to test functional roles for cav-1 in various tissues. However, neurological phenotypes associated with loss of cav-1 in mice have not been evaluated. Here, we report the results of motor and behavioral testing of CavKO mice. We find that mice deficient in cav-1 have reduced brain weight and display a number of motor and behavioral abnormalities. CavKO mice develop neurological phenotypes including clasping, abnormal spinning, muscle weakness, reduced activity, and gait abnormalities. These data suggest that cav-1 is involved in maintaining cortico-striato-pallido-thalamo-pontine pathways associated with motor control.
KW - Brain histology
KW - Caveolin
KW - Knock out mouse model
KW - Neurological phenotype
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U2 - 10.1016/j.bbr.2006.04.024
DO - 10.1016/j.bbr.2006.04.024
M3 - Article
C2 - 16750274
AN - SCOPUS:33745852268
SN - 0166-4328
VL - 172
SP - 24
EP - 32
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -