Neurofibrillary tangles have no obligatory predilection for acetylcholinesterase-rich neurons

M. Marsel Mesulam; Stephen Brimijoin; Changiz Geula

doi:10.1016/0197-4580(94)00056-5

Neurofibrillary tangles have no obligatory predilection for acetylcholinesterase-rich neurons

M. Marsel Mesulam, Stephen Brimijoin, Changiz Geula

Pharmacology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Parts of the brain that are prone to NFT formation normally contain many neurons that are intensely acetylcholinesterase (AChE)-positive. In this study, we used thioflavin-S immunofluorescence, AChE histochemistry, and AChE immunocytochemistry to investigate the possibility that intense AChE positivity may act as a perikaryal marker for the vulnerability to NFT formation. Our observations in entorhinal and motor cortices and in the subthalamic nucleus demonstrate major mismatches between the distribution of AChE-rich neurons in normal brains and the distribution of NFT in AD. There is therefore no obligatory relationship between intense AChE positivity in the premorbid period and subsequent vulnerability to tangle formation.

Original language	English (US)
Pages (from-to)	615-619
Number of pages	5
Journal	Neurobiology of aging
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/0197-4580(94)00056-5
State	Published - 1994

Keywords

Acetylcholinesterase
Alzheimer's disease
Cholinesterase
Dementia
Entorhinal cortex
Motor cortex
Neurofibrillary tangles
Nucleus basalis
Subthalamic nucleus

ASJC Scopus subject areas

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/0197-4580(94)00056-5

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title = "Neurofibrillary tangles have no obligatory predilection for acetylcholinesterase-rich neurons",

abstract = "Parts of the brain that are prone to NFT formation normally contain many neurons that are intensely acetylcholinesterase (AChE)-positive. In this study, we used thioflavin-S immunofluorescence, AChE histochemistry, and AChE immunocytochemistry to investigate the possibility that intense AChE positivity may act as a perikaryal marker for the vulnerability to NFT formation. Our observations in entorhinal and motor cortices and in the subthalamic nucleus demonstrate major mismatches between the distribution of AChE-rich neurons in normal brains and the distribution of NFT in AD. There is therefore no obligatory relationship between intense AChE positivity in the premorbid period and subsequent vulnerability to tangle formation.",

keywords = "Acetylcholinesterase, Alzheimer's disease, Cholinesterase, Dementia, Entorhinal cortex, Motor cortex, Neurofibrillary tangles, Nucleus basalis, Subthalamic nucleus",

author = "Mesulam, {M. Marsel} and Stephen Brimijoin and Changiz Geula",

note = "Funding Information: We thank Leah Christie, Kristin Bouvr, and Tamar Calabrese for their expert secretarial and technical assistance. This work was supported in part by the Javits Neuroscience Investigator Award NS20285 (M.M.M.), an Alzheimer' s Disease Research Center Grant AG05134 and a grant from the National Institutes for Aging AG10282 (C.G.).",

year = "1994",

doi = "10.1016/0197-4580(94)00056-5",

language = "English (US)",

volume = "15",

pages = "615--619",

journal = "Neurobiology of aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Neurofibrillary tangles have no obligatory predilection for acetylcholinesterase-rich neurons

AU - Mesulam, M. Marsel

AU - Brimijoin, Stephen

AU - Geula, Changiz

N1 - Funding Information: We thank Leah Christie, Kristin Bouvr, and Tamar Calabrese for their expert secretarial and technical assistance. This work was supported in part by the Javits Neuroscience Investigator Award NS20285 (M.M.M.), an Alzheimer' s Disease Research Center Grant AG05134 and a grant from the National Institutes for Aging AG10282 (C.G.).

PY - 1994

Y1 - 1994

N2 - Parts of the brain that are prone to NFT formation normally contain many neurons that are intensely acetylcholinesterase (AChE)-positive. In this study, we used thioflavin-S immunofluorescence, AChE histochemistry, and AChE immunocytochemistry to investigate the possibility that intense AChE positivity may act as a perikaryal marker for the vulnerability to NFT formation. Our observations in entorhinal and motor cortices and in the subthalamic nucleus demonstrate major mismatches between the distribution of AChE-rich neurons in normal brains and the distribution of NFT in AD. There is therefore no obligatory relationship between intense AChE positivity in the premorbid period and subsequent vulnerability to tangle formation.

AB - Parts of the brain that are prone to NFT formation normally contain many neurons that are intensely acetylcholinesterase (AChE)-positive. In this study, we used thioflavin-S immunofluorescence, AChE histochemistry, and AChE immunocytochemistry to investigate the possibility that intense AChE positivity may act as a perikaryal marker for the vulnerability to NFT formation. Our observations in entorhinal and motor cortices and in the subthalamic nucleus demonstrate major mismatches between the distribution of AChE-rich neurons in normal brains and the distribution of NFT in AD. There is therefore no obligatory relationship between intense AChE positivity in the premorbid period and subsequent vulnerability to tangle formation.

KW - Acetylcholinesterase

KW - Alzheimer's disease

KW - Cholinesterase

KW - Dementia

KW - Entorhinal cortex

KW - Motor cortex

KW - Neurofibrillary tangles

KW - Nucleus basalis

KW - Subthalamic nucleus

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AN - SCOPUS:0028025192

SN - 0197-4580

VL - 15

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JO - Neurobiology of aging

JF - Neurobiology of aging

IS - 5

ER -

Neurofibrillary tangles have no obligatory predilection for acetylcholinesterase-rich neurons

Abstract

Keywords

ASJC Scopus subject areas

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