Neurocognitive outcomes in congenital diaphragmatic hernia survivors: a cross-sectional prospective study

Katarina Bojanić, Marina Grubić, Ana Bogdanić, Jurica Vuković, Toby N. Weingarten, Andrea R. Huebner, Juraj Sprung, Darrell R. Schroeder, Ruža Grizelj

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background/purpose Congenital diaphragmatic hernia (CDH) survivors may have persistent neurocognitive delays. We assessed neurodevelopmental outcomes in CDH survivors from infancy to late teenage years. Methods A cross-sectional study was conducted on 37 CDH survivors to examine neurocognitive functioning. Overall cognitive score was tested with the early learning composite (ELC) of Mullen Scales of Early Learning (n = 19), and Full Scale IQ (FSIQ) of Wechsler Intelligence Scale for Children–Fourth Edition (n = 18). Results ELC was 85.7 ± 16.4, lower than the expected norm of 100, P = 0.004, and 6 survivors had moderate, and 3 severe delay, which is not greater than expected in the general population (P = 0.148). FSIQ was 99.6 ± 19.1, consistent with the expected norm of 100, P = 0.922, and 3 survivors had moderate and 2 severe delay, which is greater than expected (P = 0.048). Although ELC was lower than FSIQ (P = 0.024), within each testing group overall cognitive ability was not associated with participant age (ELC, P = 0.732; FSIQ, P = 0.909). Longer hospital stay was the only factor found to be consistently associated with a worse cognitive score across all participants in our cohort. Conclusions A high percentage of survivors with CDH have moderate to severe cognitive impairment suggesting that these subjects warrant early testing with implementation of therapeutic and educational interventions.

Original languageEnglish (US)
Pages (from-to)1627-1634
Number of pages8
JournalJournal of pediatric surgery
Issue number10
StatePublished - Oct 1 2016


  • Congenital diaphragmatic hernia
  • Cross-sectional study
  • Early learning composite score, ELC
  • Full scale IQ, FSIQ
  • Mullen Scales of Early Learning, MSEL
  • Wechsler Intelligence Scale–Fourth Edition, WISC-IV

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery


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