Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia

Diana Petroi, Joseph R. Duffy, Andrew Borgert, Edythe A. Strand, Mary M. Machulda, Matthew L. Senjem, Clifford R. Jack, Keith A. Josephs, Jennifer L. Whitwell

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


While phonologic errors may be one of the salient features of the logopenic variant of primary progressive aphasia (lvPPA), sparse data are available on their neuroimaging correlates. The purpose of this study was to identify brain regions associated with different types of phonologic errors across several tasks for participants with lvPPA. Correlational analyses between phonologic errors across tasks most likely to elicit such errors and specific left hemisphere gray matter volume regions were conducted for 20 participants. Findings point to the inferior parietal lobe and supramarginal gyrus as being the most relevant correlates. Atrophy in these regions may increase the likelihood of making phonologic errors in lvPPA, particularly substitution error types. Our results provide support for neuroanatomical correlates of phonologic errors in the parietal region, which is consistent with previous findings of temporoparietal cortex involvement/atrophy in lvPPA.

Original languageEnglish (US)
Article number104773
JournalBrain and Language
StatePublished - May 2020


  • Logopenic progressive aphasia
  • Neuroanatomical correlates
  • Neuroimaging
  • Phonologic errors
  • Primary progressive aphasia

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing


Dive into the research topics of 'Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia'. Together they form a unique fingerprint.

Cite this