Neural control of blood pressure in women: differences according to age

Ana B. Peinado, Ronee E. Harvey, Emma C. Hart, Nisha Charkoudian, Timothy B. Curry, Wayne T. Nicholson, B. Gunnar Wallin, Michael J. Joyner, Jill N. Barnes

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Purpose: The blood pressure “error signal” represents the difference between an individual’s mean diastolic blood pressure and the diastolic blood pressure at which 50% of cardiac cycles are associated with a muscle sympathetic nerve activity burst (the “T50”). In this study we evaluated whether T50 and the error signal related to the extent of change in blood pressure during autonomic blockade in young and older women, to study potential differences in sympathetic neural mechanisms regulating blood pressure before and after menopause. Methods: We measured muscle sympathetic nerve activity and blood pressure in 12 premenopausal (25 ± 1 years) and 12 postmenopausal women (61 ± 2 years) before and during complete autonomic blockade with trimethaphan camsylate. Results: At baseline, young women had a negative error signal (−8 ± 1 versus 2 ± 1 mmHg, p < 0.001; respectively) and lower muscle sympathetic nerve activity (15 ± 1 versus 33 ± 3 bursts/min, p < 0.001; respectively) than older women. The change in diastolic blood pressure after autonomic blockade was associated with baseline T50 in older women (r = −0.725, p = 0.008) but not in young women (r = −0.337, p = 0.29). Women with the most negative error signal had the lowest muscle sympathetic nerve activity in both groups (young: r = 0.886, p < 0.001; older: r = 0.870, p < 0.001). Conclusions: Our results suggest that there are differences in baroreflex control of muscle sympathetic nerve activity between young and older women, using the T50 and error signal analysis. This approach provides further information on autonomic control of blood pressure in women.

Original languageEnglish (US)
Pages (from-to)157-165
Number of pages9
JournalClinical Autonomic Research
Issue number3
StatePublished - Jun 1 2017


  • Aging
  • Baroreflex function
  • Menopause
  • Sympathetic nerve activity

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology


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