Nephrocalcinosis: Re-defined in the era of endourology

Nicole L. Miller, Mitchell R. Humphreys, Fredric L. Coe, Andrew P. Evan, Sharon B. Bledsoe, Shelly E. Handa, James E. Lingeman

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Nephrocalcinosis generally refers to the pres ence of calcium salts within renal tissue, but this term is also used radiologically in diagnostic imaging in disease states that also produce renal stones, so that it is not always clear whether it is tissue calcifications or urinary calculi that give rise to the characteristic appearance of the kidney on x-ray or computed tomography (CT). Recent advances in endoscopic imaging now allow the visual distinction between stones and papillary nephrocalcinosis, and intra-renal endoscopy can also verify the complete removal of urinary stones, so that subsequent radiographic appearance can be confidently attributed to nephrocalcinosis. This report shows exemplary cases of primary hyperparathy roidism, type I distal renal tubular acidosis, medullary sponge kidney, and common calcium oxalate stone for mation. In the first three cases - all being conditions commonly associated with nephrocalcinosis - it is shown that the majority of calcifications seen by radiograph may actually be stones. In common calcium oxalate stones formers, it is shown that Randall's plaque can appear as a small calculus on CT scan, even when calyces are known to be completely clear of stones. In the current era with the use of non-contrast CT for the diagnosis of nephrolithiasis, the finding of calcifications in close association with the renal papillae is common. Distinguishing nephrolithiasis from nephrocalcinosis requires direct visual inspection of the papillae and so the diagnosis of nephrocalcinosis is essentially an endoscopic, not radiologic, diagnosis.

Original languageEnglish (US)
Pages (from-to)421-427
Number of pages7
JournalUrological Research
Issue number6
StatePublished - Dec 2010


  • Hyperparathyroidism
  • Kidney calculi
  • Medullary sponge
  • Nephrocalcinosis
  • Renal tubular acidosis

ASJC Scopus subject areas

  • Urology


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