Nanoparticles for combination drug therapy

Liang Ma, Manish Kohli, Andrew Smith

Research output: Contribution to journalReview articlepeer-review

213 Scopus citations


Nanoparticles have recently emerged as a promising class of carriers for the co-delivery of multiple drugs. Combination therapies of small-molecule drugs are common in clinical practice, and it is anticipated that packaging into single macromolecular carriers will enable drug release in precisely balanced ratios and rates and in selectively targeted tissues and cells. This vast level of pharmacological control is intriguing, especially from the perspective of tailoring personalized treatments with maximized therapeutic synergy for individual patients. Here, we discuss promising formulations and opportunities to employ advanced screening tools and new animal models of disease that can improve chances for successful clinical translation.

Original languageEnglish (US)
Pages (from-to)9518-9525
Number of pages8
JournalACS Nano
Issue number11
StatePublished - Nov 26 2013

ASJC Scopus subject areas

  • General Materials Science
  • General Engineering
  • General Physics and Astronomy


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