Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG)-Positive Optic Perineuritis

A. Sebastian Lopez-Chiriboga, Gregory Van Stavern, Eoin P. Flanagan, Sean J. Pittock, Jim Fryer, M. Tariq Bhatti, John J. Chen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but the majority of cases are idiopathic. Myelin oligodendrocyte glycoprotein (MOG)-IgG-positive optic neuritis has been reported to be associated with optic nerve sheath enhancement. This report describes two MOG-IgG patients with clinical, radiological and therapeutic response consistent with optic perineuritis. MOG-IgG may account for many cases of previously described idiopathic optic perineuritis. Vision loss with optic nerve sheath enhancement on MRI should prompt testing for MOG-IgG.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
Issue number1
StatePublished - Jan 2 2020


  • Optic perineuritis
  • aquaporin-4 (AQP4)
  • myelin oligodendrocyte glycoprotein (MOG)
  • optic nerve sheath
  • optic neuritis

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology


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