TY - JOUR
T1 - Mycobacterium abscessus disease in lung transplant recipients
T2 - Diagnosis and management
AU - Chandrashekaran, Satish
AU - Escalante, Patricio
AU - Kennedy, Cassie C.
N1 - Funding Information:
Cassie C. Kennedy M.D. is supported by the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic , Rochester, MN and the NHLBI grant K23 HL128859 from the National Institutes of Health . The manuscript contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH .
Publisher Copyright:
© 2017 The Authors
PY - 2017/12
Y1 - 2017/12
N2 - Mycobacterium abscessus complex (MAbsC) disease in lung transplant recipients is increasingly being recognized as an important cause of graft function decline and suboptimal outcomes. Lung transplant recipients appear to be at the highest risk of MAbsC among solid organ transplant recipients, as they have more intense immunosuppression, and the organisms preferentially inhabit the lungs. MAbsC is the most resistant species of rapidly growing mycobacteria and difficult to treat, causing considerable mortality and morbidity in immunocompetent and immunosuppressed patients. Herein we describe the risk factors, epidemiology, clinical features, diagnostics, and treatment strategies of MAbsC in lung transplant candidates and recipients.
AB - Mycobacterium abscessus complex (MAbsC) disease in lung transplant recipients is increasingly being recognized as an important cause of graft function decline and suboptimal outcomes. Lung transplant recipients appear to be at the highest risk of MAbsC among solid organ transplant recipients, as they have more intense immunosuppression, and the organisms preferentially inhabit the lungs. MAbsC is the most resistant species of rapidly growing mycobacteria and difficult to treat, causing considerable mortality and morbidity in immunocompetent and immunosuppressed patients. Herein we describe the risk factors, epidemiology, clinical features, diagnostics, and treatment strategies of MAbsC in lung transplant candidates and recipients.
KW - Lung infection
KW - Lung transplant
KW - Mycobacterial abscessus complex
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U2 - 10.1016/j.jctube.2017.08.002
DO - 10.1016/j.jctube.2017.08.002
M3 - Review article
AN - SCOPUS:85028763948
SN - 2405-5794
VL - 9
SP - 10
EP - 18
JO - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
JF - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
ER -