TY - JOUR
T1 - Multistage vector (MSV) therapeutics
AU - Wolfram, Joy
AU - Shen, Haifa
AU - Ferrari, Mauro
N1 - Funding Information:
This work was funded by the Houston Methodist Research Institute . Partial funds were acquired from: the Ernest Cockrell Jr. Distinguished Endowed Chair (M.F.), the US Department of Defense ( W81XWH-09-1-0212 , W81XWH-12-1-0414 ) (M.F.), the National Institute of Health ( U54CA143837 , U54CA151668 ) (M.F.), Nylands Nation Finland (J.W.), Victoriastiftelsen Finland (J.W.), and the Cancer Prevention Research Institute of Texas ( RP121071 ) (M.F. and H.S.). We sincerely thank Matthew Landry for assistance with figures.
Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/12/10
Y1 - 2015/12/10
N2 - One of the greatest challenges in the field of medicine is obtaining controlled distribution of systemically administered therapeutic agents within the body. Indeed, biological barriers such as physical compartmentalization, pressure gradients, and excretion pathways adversely affect localized delivery of drugs to pathological tissue. The diverse nature of these barriers requires the use of multifunctional drug delivery vehicles that can overcome a wide range of sequential obstacles. In this review, we explore the role of multifunctionality in nanomedicine by primarily focusing on multistage vectors (MSVs). The MSV is an example of a promising therapeutic platform that incorporates several components, including a microparticle, nanoparticles, and small molecules. In particular, these components are activated in a sequential manner in order to successively address transport barriers.
AB - One of the greatest challenges in the field of medicine is obtaining controlled distribution of systemically administered therapeutic agents within the body. Indeed, biological barriers such as physical compartmentalization, pressure gradients, and excretion pathways adversely affect localized delivery of drugs to pathological tissue. The diverse nature of these barriers requires the use of multifunctional drug delivery vehicles that can overcome a wide range of sequential obstacles. In this review, we explore the role of multifunctionality in nanomedicine by primarily focusing on multistage vectors (MSVs). The MSV is an example of a promising therapeutic platform that incorporates several components, including a microparticle, nanoparticles, and small molecules. In particular, these components are activated in a sequential manner in order to successively address transport barriers.
KW - Biological barriers
KW - Cancer therapy
KW - Geometrical targeting
KW - Porous silicon
KW - Transport oncophysics
UR - http://www.scopus.com/inward/record.url?scp=84947485811&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947485811&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2015.08.010
DO - 10.1016/j.jconrel.2015.08.010
M3 - Article
C2 - 26264836
AN - SCOPUS:84947485811
SN - 0168-3659
VL - 219
SP - 406
EP - 415
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -